FELINE ARTHRITIS AND NSAID STUDY
Did you know that there are no approved medications for chronic pain in cats? One reason for this is that there are no validated ways to determine if cats have chronic musculoskeletal pain. The lack of validated ways to assess pain makes it difficult for veterinarians to know if your cat is suffering from chronic pain. This study will help Veterinarians to determine if pain is present, and guide treatment by being able to assess how well those treatments are working. Researchers at NC State are evaluating a long-term non-steroidal anti-inflammatory drug (NSAID) for treatment of chronic musculo-skeletal disorder (CMSD), including arthritis, in cats. Participants will be cats with naturally occurring CMSD. Cats will be treated with placebo and/or investigational NSAID for a total of 8 weeks.
One of the ways we will be evaluating your cat is by finding activities that you feel your cat does not do as well as he/she used to or may not even do anymore. To help trigger your thinking, here are some helpful hints that might remind you of something. Think back to when your cat was younger and the way he/she acted/behaved. Look for signs such as: Walking, difficulty moving after a long rest, running, and difficulty using stairs.
Client owned, adult, primarily indoor-only cats (≥ 1year of age) Noted by owner to be “slowing down” or have “mobility impairment” or already have a diagnosis of arthritis No other suspected or diagnosed diseases Owner able to dose orally with 1-2 small tablets Body weight ≥ 2.5kg and ≤12.0kg Stable lifestyle for the duration of study (no moves, new baby/pet, long vacations, no food changes or new medications/supplements)
Corticosteroids, NSAIDs, opioid analgesics or other anti-inflammatory agents. Wash out period is 2-4 weeks if able to discontinue use. Putative analgesics (e.g. gabapentin, amantadine, tramadol), tricyclic-antidepressants (e.g. amitryptylline or clomipramine), or selective serotonin reuptake inhibitors (e.g. fluoxetine) are permitted as long as the cat has been receiving them at a stable dose for 4 weeks. Previous intolerance to NSAIDs
Free physical, orthopedic, and neurologic exams Free radiographs Free blood work (including T4 level) and urinalysis
Shared from : https://cvm.ncsu.edu/research/clinical-trials/list/?species=cats